New Automated Multiplex Assay for Bone Turnover Markers in Osteoporosis

New automated multiplex assay for bone turnover markers in osteoporosis.

BACKGROUND Serum C-terminal cross-linked telopeptide of type I collagen (CTX-I), N-terminal propeptide of type I collagen (PINP), and osteocalcin (OC) are among the most sensitive bone turnover markers for evaluating osteoporosis. Each marker is currently measured individually by manual or automated immunoassays that are time consuming and require substantial sample volume. We evaluated the per...

Bone Turnover Markers for Diagnosis and Management of Osteoporosis and Diseases Associated with High Bone Turnover

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Biochemical markers of bone turnover and their utility in osteoporosis.

O steoporosis, an age-related, degenerative disease of bone is an asymptomatic disease that is diagnosed after an already unacceptable loss of bone has occurred. Alternatively, a compression fracture may lead to the initial diagnosis. Diagnosis is established by bone mineral density (BMD) at the hip and/or spine.1 BMD is a static measure of bone composition, reflecting its “history,” and detect...

Biochemical bone turnover markers: significance in patients with osteoporosis.

UNLABELLED Osteoporosis is a systemic disease, which is characterized by reduced bone mass and microarchitectural deterioration of the bone tissue, resulting in an increased risk of fracture. Since osteoporosis is today a disease with high incidence rate, the aim of this study was to determine a correlation between bone mass density (BMD) and concentration of biochemical bone turnover markers--...

Serum Leptin and Bone Turnover Markers in Postmenopausal Osteoporosis